Thesis Directed

  • 2015, PhD Thesis

    Development of Molecular PET/CT imaging-based IMRT Treatment Planning and quantification of the impact of image reconstruction algorithms on local tumor control

  • 2015, PhD Thesis

    Design, modeling and performance evaluation of dedicated brain positron emission tomography with high resolution and sensitivity using Monte Carlo simulation

  • 2015, PhD Thesis

    Design, modeling and performance evaluation of small animal PETusing Monte Carlo simulation

  • 2014, PhD Thesis

    Design, Construction and Performance Evaluation of a Rotating Slit-Hole Collimator for Small-Animal SPECT Imaging

  • 2014, PhD Thesis

    A Novel hybrid method (protocol design and image segmentation) for generation of attenuation map at 511 keV from MR images in pelvis region for MR-based Attenuation correction in PET/MRI systems

  • 2014, MSc Thesis

    Implementation of quantitative analysis capability on the high resolution SPECT images in HiReSPECT system

  • 2014, MSc Thesis

    Motion compensation in cardiac SPECT imaging

  • 2013, MSc Thesis

    Design and optimization of oncologic imaging protocol in Dsicovery 690 PET/CT scanner based on clinical and phantom study

  • 2013, MSc Thesis

    Evaluation of the benefits of time of flight technique in PET imaging using quantitative and qualitative analysis of clinical and phantom images

  • 2013, MSc Thesis

    Design and Implementation of Performance Evaluation Protocol for PET/CT scanner based on International Standards

  • 2012, MSc Thesis

    Design, modeling and performance evaluation of small animal SPECT device with oblique detectors using Monte Carlo simulation

  • 2012, MSc Thesis

    Performance evaluation and optimization of a small field of view gamma camera and gamma probe used for the lymph nodes surgery using experimental measurements and Monte Carlo simulation

  • 2012, MSc Thesis

    Quantification and Correction of Metal Artifacts Arising from Pacemaker and ICD Leads in CT-based Attenuation Correction of Cardiac SPECT Imaging

  • 2012, MSc Thesis

    Designing, modeling and performance evaluation of micro-CT for small animal imaging using Monte Carlo simulation

  • 2012, MSc Thesis

    Implementation of Attenuation Correction Algorithm For Small Animal SPECT Imaging Using Atlas-Based Methods

  • 2011, MSc Thesis

    Quantification of the influence of misregistration between CT and SPECT images on the accuracy of CT-based attenuation correction of cardiac images in hybrid SPECT/CT systems

  • 2011, MSc Thesis

    Generation of Attenuation Map from MR images for Attenuation-Correction of PET data in Head Area: Focusing on Segmentation of Bone from Air Cavities

  • 2010, MSc Thesis

    Quantification of the influence of respiratory and cardiac motion induced mis alignment between CT and PET data of diagnosis accuracy of hart disease in cardiac PET/CT imaging

  • 2010, PhD Thesis

    Generation of attenuation map for hybrid PET/MRI systems using MRI image segmentation of torso based on bones morphology

  • 2010, PhD Thesis

    Reduction of Respiratory Induced Artifact in PET/CT Imaging Using Virtual Average CT

  • 2010, PhD Thesis

    Improving the Accuracy of Energy mapping algorithm in CT-Based Attenuation Correction of PET data Using Energy Sensitive CT

  • 2009, MSc Thesis

    Design and Performance Evaluation of Small Animal Gamma Camera Detection System Based on Pixelated Crystal Using Monte Carlo Simulation

  • 2009, MSc Thesis

    Modeling and optimization of detection system in multiple head small animal PET scanner using Monte Carlo method

  • 2009, MSc Thesis

    Quantification of Respiratory Induced Artifact in CT- Based Attenuation Correction of PET Data Using NCAT Phantom and Analytic Modeling in Lung Imaging

  • 2008, MSc Thesis

    A Novel Approach for Implementation of Dual Energy Mapping Technique in CT-Based Attenuation Correction Using Single kVP Imaging: A Feasibility Study

  • 2008, MSc Thesis

    Monte Carlo Characterization of Scattered Radiation in 64 Volumetric CT Using GATE

  • 2008, MSc Thesis

    Monte Carlo Modeling of RRPET Using GATE

  • 2008, MSc Thesis

    Noise Reduction on Ultra Low Dose CT images

  • 2008, MSc Thesis

    Dual Energy CT Imaging: Application in CT Based Attenuation Correction in PET ", Supervisor

  • 2008, MSc Thesis

    Monte Carlo assessment of the Influence of X-Ray Anode Surface Roughness on X-ray Spectra

  • 2008, MSc Thesis

    CTDI Measurement using gel dosimetry in 64 slice CT scanner

  • 2008, PhD Thesis

    Monte Carlo Assessment of photonutron contamination in Medical linear Accelerators

  • 2008, MSc Thesis

    Reduction of Dental Filling Artifact in CT-Based Attenuation Correction of PET Images

  • 2007, MSc Thesis

    Comparative assessment of different energy mapping methods for generation of attenuation map at 511 keV from CT images in hybrid PET/CT systems

  • 2007, PhD Thesis

    Optimization of dedicated gamma camera for high performance breast tumor imaging using Monte Carlo simulation

  • 2007, MSc Thesis

    Calculation of scatter profile in 64 slice CT scanners using experimental measurement and Monte Carlo simulation

  • 2007, MSc Thesis

    Improvement of image quality and patient’s dose reduction in 64 slice CT scanner by optimization of x-ray spectra filtration using experimental measurement and Monte Carlo simulation

  • 2006, MSc Thesis

    Monte Carlo assessment of the impact of inter crystal scattering on PET scanner’s PSF as a function of crystal size and material

  • 2006, MSc Thesis

    Evaluation of Scatter and Septal Penetration Components in LEGP and HEGP Collimator Using Monte Carlo Simulation

  • 2006, MSc Thesis

    Monte Carlo modeling and performance prediction of slit-slat collimator in low energy SPECT imaging using GATE

  • 2006, MSc Thesis

    Monte Carlo investigation of Time-of-Flight benefits for fully 3D PET

Developed Imaging and Measurement Systems

  • High Resolution Animal SPECT Imaging System (HiReSPECT)

    HiReSPECT provides the highest performance and versatility available to address your preclinical imaging research needs from academic and translational research to drug discovery and development. Small animal imaging is an emerging field which has an impact on various biomedical research areas such as neurology, oncology, cardiology, immunology and infection biology. The Pharmaceutical industries and research centers will profit from SPECT system as they accelerate drug and biomarker development by yielding more reliable in vivo results and cost effective study design. The HiReSPECT is a dual head small animal SPECT imaging system that provides in vivo high resolution three-dimensional (3D) images of physiological functions in small labratory animals.
  • Infra Operative Gamma Camera (SurgoSight)

    Intra-operative Lymphoscintigraphy portable mini gamma camera Research Center for Molecular and Cellular Imaging Medical Imaging Systems Group
  • Gamma Probe (SurgeoGuide)

    Due to high prevalence of breast cancer in females, there are annually lots of breast surgical operations for removal of malignant tumors. However, failure in discovery and removal of cancerous lymph nodes will lead to metastasis of cancer in the patient. Currently, there are some methods with different degrees of accuracy, cost, and ease to detect sentinel nodes. Amongst all of them, the most common and the most favorite device for surgeons is “Gamma Probe” providing an easy-to-use small hand-held tool with the capability of detection and localization of sentinel lymph nodes not only in breast cancer but also for some masculine types of cancers where detection of sentinel nodes is mandatory. We developed such a gamma probe system in two models: SURGEOGUIDE and SURGEOGUIDE II. Both models passed international certificates and have Iran MOH production license.
  • Urea Breath Test System, UBT (HeliGuide)

    Helicobacter pylori is a gram-negative spirally shaped bacteria that exclusively exists in the mucosa of the stomach, particularly in the antrum. Helicobacter pylori causes gastritis which in turn can lead to ulcers and eventually cancer. Hp-infection can be confirmed with different methods and tests such as gastroscopy, Urea Breath Tests (UBT), stool-antigen and serology. UBT is recommended by European Helicobacter pylori experts as the first choice and the most reliable non-invasive test for diagnosing an active infection as well as for follow-up of eradication of infection. The HeliGuide System works with the 14C isotope as a label. It is a completely “dry” method built around two key components; a single use disposable breath-collecting unit called BreathCard, and a 14CO2 breath analyzer, called HeliGuide Analyzer.
  • Dedicated Cardiac SPECT Imaging System (RoboSPECT)

    Nuclear medicine is a medical specialty that uses radioactive tracers (radiopharmaceuticals) to assess bodily functions and diagnose and treat disease. The most widely used filed in nuclear medicine is cardiac SPECT imaging that provides the information to diagnose the prognosis of coronary artery disease and heart muscle damage following an infarction.The RoboSPECT system is designed and developed for dedicated cardiac SPECT imaging. The RoboSPECT system uses three swivel motors delivering the robotic movements and providing the circular and noncircular SPECT movement. This design has some advantages including decreasing patient-to-detector distance during scan, open gantry design to avoid intimidating patients, and increasing the durability due to use of rotational arm instead of linear movement.
  • Cardiac SPECT Imaging:ProSPECT Model

    Cardiac imaging has become an integrated part in the diagnostic and prognostic work-up of patients with cardiovasular disease. We designed and developed a dedicated cardiac SPECT system for cardiac imaging called ProSPECT. The ProSPECT scanner designed with patient’s comport in mind. The scanner provides both supine and prone imaging with a small footprint. The system increases patient’s comport specially patients with claustrophobia disorder because the patient’s head comes out of the bore of gantry during the scanning process. This dedicated cardiac imaging system introduces an optimized FOV to minimize inappropriate activity uptake of other organs.
  • Xtrim PET


International and National Patent

  • 2016

    US Patent, 2016, Pub. No. US 2016/0220204 A1, Robotic System for Cardiac Imaging", Provisional Patent

  • 2016

    US Patent, 2016, Pub. No. US 2016/0116604 A1 Desktop Open-Gantry SPECT Imaging System Using Tilted Detector

  • 2013

    US Patent, 2013, Pub. No. US 8,503,748 B2, Non Linear Recursive Filter for Medical Image Processing

  • 2013

    Iran Patent 2013/80617, Adjustable FOV for Rat and Mice Imaging In HiReSPECT Scanner

  • 2013

    Iran Patent 2013/80821, A Filter for Processing of High Count Rate Detectors

  • 2013

    Iran Patent 2013/82892, Resolution Recovery Reconstruction in Animal SPECT System

  • 2017

    •US Patent, 2017, No. US 62/429,763 " AUTOMATIC 2D PEAK DETECTION FOR CALIBRATION OF GAMMA DETECTOR BLOCK IMAGES"

  • 2017

    •US Patent, 2017, No. US 62/435,877 " A Novel Method for Reduction of Positron Range in High-Resolution PET Imagingr"

  • 2018

    US Patent, 2018,NO 15920426 "Single photon emission computed tomography imaging with a spinning parallel-slat collimator"

    A method and a system for single photon emission computed tomography (SPECT) imaging capable of performing a rapid acquisition of imaging data. The SPECT imaging system, placed at a fixed radial distance from the center of an object being imaged, includes a gamma detector and a collimator. The collimator, mounted on the gamma detector, includes a plurality of parallel slats, each perpendicular to the surface of the gamma detector. The method implemented by this system rapidly reconstructs a high-resolution and high-sensitivity image.

  • 2018

    US Patent,2018 ,No 9986960, "Robotic system for SPECT imaging"

    A robotic arm, movable in three rotational degrees of freedom has a base end and a distal end supporting SPECT imaging detectors. A patient support assembly is movable in a linear degree of freedom. A controller causes the robotic arm to move the SPECT imaging detectors, in three dimensions, around the patient's body to obtain SPECT images. The control causes the patient support assembly to move along the linear degree of freedom, maintaining alignment of the patient's body with the SPECT imaging detectors.

  • 2018

    US Patent,2018, No 15847809, "Positron range reduction in positron emission tomography imaging"

    Methods and systems are disclosed, including a method for confining an annihilation range of a positron, from a plurality of positrons emitted from an object being imaged in a positron emission tomography (PET) imaging system. Confining the annihilation includes applying a stochastic multidimensional time varying magnetic field on the positron. Optionally, the stochastic multidimensional time varying magnetic field includes components in each of three dimensions.

  • 2018

    US Patent, No 15829808,"Peak detection in a two dimensional image"

    An improved method for peak detection in a two-dimensional image is disclosed. In one implementation, the method includes one or more of the following steps: generating a smooth image from the two-dimensional image, detecting a plurality of local peaks in the smooth image, detecting a plurality of true peaks among the plurality of local peaks, and generating a peak-detected image from the smooth image. The smooth image includes a plurality of pixels, where each pixel of the plurality of pixels has an intensity level and an address. The address includes a row number and a column number. The peak-detected image includes a first true peaks subset from the plurality of true peaks. In one implementation, the intensity level of each true peak of the first true peaks subset is higher than an intensity threshold. The method further includes localizing at least one true peak of the first true peaks subset in the peak …


Developed Packages

  • M.R. Ay et al. MCNP4C-based Monte Carlo simulator for fan- and cone-beam x-ray CT, Presented in 14th International Conference of Medical Physics (ICMP 2005). Nuremberg, Germany, Sept. 14-17

  • M.R. Ay et al. Monte Carlo Simulation Package for Scintillation Cameras Operation in Single photon and Coincidence Imaging mode, Presented in Annual Congress of the European Association of Nuclear Medicine(EANM03), 2003, Amsterdam, Netherlands

  • M.R. Ay et al. Implementation of an X-ray Spectra Database in Diagnostic Radiology Energy Range Based on all computational Models

  • M.R. Ay et al. Implementation of an X-ray Spectra Database in Mammography Energy Range Based on all computational Models